Loss to gain: pseudogenes in microorganisms, focusing on eubacteria, and their biological significance.
Appl Microbiol Biotechnol
; 108(1): 328, 2024 May 08.
Article
en En
| MEDLINE
| ID: mdl-38717672
ABSTRACT
Pseudogenes are defined as "non-functional" copies of corresponding parent genes. The cognition of pseudogenes continues to be refreshed through accumulating and updating research findings. Previous studies have predominantly focused on mammals, but pseudogenes have received relatively less attention in the field of microbiology. Given the increasing recognition on the importance of pseudogenes, in this review, we focus on several aspects of microorganism pseudogenes, including their classification and characteristics, their generation and fate, their identification, their abundance and distribution, their impact on virulence, their ability to recombine with functional genes, the extent to which some pseudogenes are transcribed and translated, and the relationship between pseudogenes and viruses. By summarizing and organizing the latest research progress, this review will provide a comprehensive perspective and improved understanding on pseudogenes in microorganisms. KEY POINTS ⢠Concept, classification and characteristics, identification and databases, content, and distribution of microbial pseudogenes are presented. ⢠How pseudogenization contribute to pathogen virulence is highlighted. ⢠Pseudogenes with potential functions in microorganisms are discussed.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bacterias
/
Seudogenes
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Año:
2024
Tipo del documento:
Article
País de afiliación:
China