Efficient Radiolabeling of Proteins and Antibodies via Maleamate-Cysteine Bioconjugation.
ACS Med Chem Lett
; 15(5): 691-695, 2024 May 09.
Article
en En
| MEDLINE
| ID: mdl-38746876
ABSTRACT
The study introduces a novel maleamate-based prosthetic group specifically designed for efficient, site-specific radioiodination of biomolecules that contain or are modified with cysteine residues. This strategy is a compelling alternative to the conventional maleimide-based approach, demonstrating outstanding attributes such as high radiochemical yield, rapid reaction kinetics, applicability in aqueous media at neutral pH, and exceptional stability under a competitive environment.
Texto completo:
1
Banco de datos:
MEDLINE
Idioma:
En
Revista:
ACS Med Chem Lett
Año:
2024
Tipo del documento:
Article