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Interleukin-1ß moderates the relationships between middle frontal-mACC/insular connectivity and depressive symptoms in bipolar II depression.
Xiao, Hongqi; Cao, Yuan; Lizano, Paulo; Li, Meng; Sun, Huan; Zhou, Xiaoqin; Deng, Gaoju; Li, Jiafeng; Chand, Tara; Jia, Zhiyun; Qiu, Changjian; Walter, Martin.
Afiliación
  • Xiao H; Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Cao Y; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena 07743, Germany; Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R
  • Lizano P; The Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Division of Translational Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; The Department of Psychiatry, Harvard Medical School, Boston
  • Li M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena 07743, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jena-Magdeburg, Germany; Clinical Affective Neuroimaging Laboratory (CANLAB), Leipziger
  • Sun H; Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Zhou X; Department of Clinical Research Management, West China Hospital of Sichuan University, Chengdu 610041, PR China.
  • Deng G; Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Li J; Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China.
  • Chand T; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena 07743, Germany; Department of Clinical Psychology, Friedrich Schiller University Jena, Am Steiger 3-1, 07743 Jena, Germany; Jindal Institute of Behavioural Sciences, O. P. Jindal Global University (Sonipat), Haryana, India.
  • Jia Z; Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: zhiyunjia@hotmail.com.
  • Qiu C; Mental Health Center, West China Hospital of Sichuan University, Chengdu 610041, China. Electronic address: qiuchangjian@wchscu.cn.
  • Walter M; Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena 07743, Germany; German Center for Mental Health (DZPG), partner site Halle-Jena-Magdeburg, Germany; Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Halle-Jen
Brain Behav Immun ; 120: 44-53, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38777282
ABSTRACT
The functional alterations of the brain in bipolar II depression (BDII-D) and their clinical and inflammatory associations are understudied. We aim to investigate the functional brain alterations in BDII-D and their relationships with inflammation, childhood adversity, and psychiatric symptoms, and to examine the moderating effects among these factors. Using z-normalized amplitude of low-frequency fluctuation (zALFF), we assessed the whole-brain resting-state functional activity between 147 BDII-D individuals and 150 healthy controls (HCs). Differential ALFF regions were selected as seeds for functional connectivity analysis to observe brain connectivity alterations resulting from abnormal regional activity. Four inflammatory cytokines including interleukin (IL)-6, IL-1ß, tumor necrosis factor (TNF)-α, and C-reactive protein (CRP) and five clinical scales including Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Positive and Negative Syndrome Scale (PANSS), Columbia-Suicide Severity Rating Scale (C-SSRS), and Childhood Trauma Questionnaire (CTQ) were tested and assessed in BDII-D. Partial correlations with multiple comparison corrections identified relationships between brain function and inflammation, childhood adversity, and psychiatric symptoms. Moderation analysis was conducted based on correlation results and previous findings. Compared to HCs, BDII-D individuals displayed significantly lower zALFF in the superior and middle frontal gyri (SFG and MFG) and insula, but higher zALFF in the occipital-temporal area. Only the MFG and insula-related connectivity exhibited significant differences between groups. Within BDII-D, lower right insula zALFF value correlated with higher IL-6, CRP, and emotional adversity scores, while lower right MFG zALFF was related to higher CRP and physical abuse scores. Higher right MFG-mid-anterior cingulate cortex (mACC) connectivity was associated with higher IL-1ß. Moreover, IL-1ß moderated associations between higher right MFG-mACC/insula connectivity and greater depressive symptoms. This study reveals that abnormal functional alterations in the right MFG and right insula were associated with elevated inflammation, childhood adversity, and depressive symptoms in BDII-D. IL-1ß may moderate the relationship between MFG-related connectivity and depressive symptoms.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar / Imagen por Resonancia Magnética / Depresión / Interleucina-1beta Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar / Imagen por Resonancia Magnética / Depresión / Interleucina-1beta Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Behav Immun Asunto de la revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China