Bisindole-based small molecules as transmembrane anion transporters and potential anticancer agents.
Org Biomol Chem
; 22(24): 4987-4992, 2024 06 19.
Article
en En
| MEDLINE
| ID: mdl-38832875
ABSTRACT
Few synthetic ion transporters have been reported incorporating indole as the core moiety. We have developed a novel bisindole-based transporter capable of efficient transmembrane anion antiport. This system induced cytotoxicity in MCF-7 breast cancer cells via chloride ion homeostasis disruption and the associated ROS generation, mitochondrial membrane depolarization, and lysosomal deacidification.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Indoles
/
Antineoplásicos
Límite:
Humans
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2024
Tipo del documento:
Article
País de afiliación:
India