Rhodium-Promoted C-H Activation/Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Selection Outcomes.
Org Lett
; 26(23): 4958-4962, 2024 Jun 14.
Article
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| MEDLINE
| ID: mdl-38833318
ABSTRACT
Inspired by previous selection outcomes, we investigated and developed a rhodium-promoted C-H activation/annulation reaction of DNA-linked terminal alkynes and aromatic acids. This reaction exhibits excellent efficiency with high conversions and a broad substrate scope. Most importantly, the unique DEL-compatible conditions provide a better scenario for yielding an isocoumarin scaffold compared to conventional organic reaction conditions, and this newly developed on-DNA method has confirmed its feasibility in preparing DNA-encoded libraries.
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MEDLINE
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Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2024
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Article
País de afiliación:
China