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Experience-dependent regulation of dopaminergic signaling in the somatosensory cortex.
Jamal, Tousif; Yan, Xuan; Lantyer, Angelica da Silva; Ter Horst, Judith G; Celikel, Tansu.
Afiliación
  • Jamal T; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Yan X; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Lantyer ADS; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Ter Horst JG; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Celikel T; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; School of Psychology, Georgia Institute of Technology, Atlanta, GA, USA. Electronic address: celikel@gatech.edu.
Prog Neurobiol ; 239: 102630, 2024 Aug.
Article en En | MEDLINE | ID: mdl-38834131
ABSTRACT
Dopamine critically influences reward processing, sensory perception, and motor control. Yet, the modulation of dopaminergic signaling by sensory experiences is not fully delineated. Here, by manipulating sensory experience using bilateral single-row whisker deprivation, we demonstrated that gene transcription in the dopaminergic signaling pathway (DSP) undergoes experience-dependent plasticity in both granular and supragranular layers of the primary somatosensory (barrel) cortex (S1). Sensory experience and deprivation compete for the regulation of DSP transcription across neighboring cortical columns, and sensory deprivation-induced changes in DSP are topographically constrained. These changes in DSP extend beyond cortical map plasticity and influence neuronal information processing. Pharmacological regulation of D2 receptors, a key component of DSP, revealed that D2 receptor activation suppresses excitatory neuronal excitability, hyperpolarizes the action potential threshold, and reduces the instantaneous firing rate. These findings suggest that the dopaminergic drive originating from midbrain dopaminergic neurons, targeting the sensory cortex, is subject to experience-dependent regulation and might create a regulatory feedback loop for modulating sensory processing. Finally, using topological gene network analysis and mutual information, we identify the molecular hubs of experience-dependent plasticity of DSP. These findings provide new insights into the mechanisms by which sensory experience shapes dopaminergic signaling in the brain and might help unravel the sensory deficits observed after dopamine depletion.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Transducción de Señal / Dopamina / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Prog Neurobiol Año: 2024 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Corteza Somatosensorial / Transducción de Señal / Dopamina / Plasticidad Neuronal Límite: Animals Idioma: En Revista: Prog Neurobiol Año: 2024 Tipo del documento: Article