The effects of tumor-derived supernatants (TDS) on cancer cell progression: A review and update on carcinogenesis and immunotherapy.
Cancer Treat Res Commun
; 40: 100823, 2024.
Article
en En
| MEDLINE
| ID: mdl-38875884
ABSTRACT
Tumors can produce bioactive substances called tumor-derived supernatants (TDS) that modify the immune response in the host body. This can result in immunosuppressive effects that promote the growth and spread of cancer. During tumorigenesis, the exudation of these substances can disrupt the function of immune sentinels in the host and reinforce the support for cancer cell growth. Tumor cells produce cytokines, growth factors, and proteins, which contribute to the progression of the tumor and the formation of premetastatic niches. By understanding how cancer cells influence the host immune system through the secretion of these factors, we can gain new insights into cancer diagnosis and therapy.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Progresión de la Enfermedad
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Carcinogénesis
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Inmunoterapia
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Neoplasias
Límite:
Animals
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Humans
Idioma:
En
Revista:
Cancer Treat Res Commun
Año:
2024
Tipo del documento:
Article
País de afiliación:
Irán