Cancer metastasis through the lymphatic versus blood vessels.
Clin Exp Metastasis
; 41(4): 387-402, 2024 Aug.
Article
en En
| MEDLINE
| ID: mdl-38940900
ABSTRACT
Whether cancer cells metastasize from the primary site to the distant sites via the lymphatic vessels or the blood vessels directly into the circulation is still under intense study. In this review article, we follow the journey of cancer cells metastasizing to the sentinel lymph nodes and beyond to the distant sites. We emphasize cancer heterogeneity and microenvironment as major determinants of cancer metastasis. Multiple molecules have been found to be associated with the complicated process of metastasis. Based on the large sentinel lymph node data, it is reasonable to conclude that cancer cells may metastasize through the blood vessels in some cases but in most cases, they use the sentinel lymph nodes as the major gateway to enter the circulation to distant sites.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Vasos Sanguíneos
/
Vasos Linfáticos
/
Metástasis Linfática
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Metastasis
/
Clin. exp. metastasis
/
Clinical & experimental metastasis
Asunto de la revista:
NEOPLASIAS
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos