Your browser doesn't support javascript.
loading
Risk factors and predictors of recurrence of febrile seizures in children in Nantong, China: a retrospective cohort study.
Shen, Feifei; Lu, Leijuan; Wu, Youjia; Suo, Guihai; Zheng, Yuqin; Zhong, Xiuli; Wang, Xu; Li, Haiying.
Afiliación
  • Shen F; Department of Pediatrics, Affiliated Hospital of Nantong University, No.20 Xisi Rd, Nantong, Jiangsu, 226001, China.
  • Lu L; Department of Pediatrics, Affiliated Haimen Hospital of Xinglin College, Nantong University, Nantong, Jiangsu Province, China.
  • Wu Y; Department of Pediatrics, Affiliated Hospital of Nantong University, No.20 Xisi Rd, Nantong, Jiangsu, 226001, China.
  • Suo G; Department of Pediatrics, Affiliated Hospital of Nantong University, No.20 Xisi Rd, Nantong, Jiangsu, 226001, China.
  • Zheng Y; Department of Pediatrics, Affiliated Hospital of Nantong University, No.20 Xisi Rd, Nantong, Jiangsu, 226001, China.
  • Zhong X; Department of Gynaecology and Obstetrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
  • Wang X; Department of Science and Technology, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. sepnine@njmu.edu.cn.
  • Li H; Department of Pediatrics, Affiliated Hospital of Nantong University, No.20 Xisi Rd, Nantong, Jiangsu, 226001, China. zl070619@126.com.
BMC Pediatr ; 24(1): 420, 2024 Jul 01.
Article en En | MEDLINE | ID: mdl-38951748
ABSTRACT

BACKGROUND:

Although most children with febrile seizures (FS) have a favorable prognosis, some experience recurrence within 1-3 years. Age, peak temperature, and family history are now recognized as important risk factors for FS recurrence, yet studies in this area are lacking in China. This study aimed to investigate the risk factors for FS recurrence in children in Nantong, China, and to develop a prediction model.

METHODS:

This retrospective cohort study analyzed 463 children diagnosed with febrile seizures (FS) who presented to the Affiliated Hospital of Nantong University between January 2015 and June 2020. Basic information, disease characteristics, and laboratory and imaging data were collected. A follow-up survey was conducted one year post-discharge to assess the recurrence status of FS in children. Univariate logistic regression and random forest models were used to identify and rank the predictive ability of risk factors for recurrence.

RESULTS:

Of the 463 children with FS, 70 experienced recurrences within 1 year of discharge, resulting in a one-year recurrence rate of 15%. Age (OR = 0.61, 95% CI 0.46, 0.80, P < 0.001), duration of the first episode (OR = 1.03, 95% CI 1.00, 1.06, P = 0.040), and peak temperature (OR = 0.68, 95% CI 0.47, 0.98, P = 0.036) were identified as independent risk factors for FS recurrence. Age had the highest relative importance in predicting FS recurrence, followed by the duration of the first episode, with an area under the ROC curve of 0.717.

CONCLUSION:

Young age and duration of the first seizure are important independent risk factors for FS recurrence and are key considerations for predicting recurrence. Further research is needed to confirm the potential use of Neutrophil-lymphocyte ratio (NLR) as a predictor of FS recurrence.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Recurrencia / Convulsiones Febriles Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr / BMC pediatr. (Online) / BMC pediatrics (Online) Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Recurrencia / Convulsiones Febriles Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Asia Idioma: En Revista: BMC Pediatr / BMC pediatr. (Online) / BMC pediatrics (Online) Asunto de la revista: PEDIATRIA Año: 2024 Tipo del documento: Article País de afiliación: China