Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.
BMC Gastroenterol
; 24(1): 214, 2024 Jul 03.
Article
en En
| MEDLINE
| ID: mdl-38961334
ABSTRACT
BACKGROUND:
Platelet dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Despite clinical observations indicating abnormalities in platelet parameters among IBD patients, inconsistencies persist, and these parameters lack standardization for diagnosis or clinical assessment.METHODS:
A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases for relevant articles published up to December 16th, 2023. A random-effects model was employed to pool the weighted mean difference (WMD) and 95% confidence interval (95% CI) of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) between IBD patients and healthy controls, and subgroup analyses were performed.RESULTS:
The meta-analysis included 79 articles with 8,350 IBD patients and 13,181 healthy individuals. The results revealed significantly increased PLT and PCT levels (WMD 69.910, 95% CI 62.177, 77.643 109/L; WMD 0.046%, 95% CI 0.031%, 0.061%), and decreased MPV levels (WMD -0.912, 95% CI -1.086, -0.739 fL) in IBD patients compared to healthy individuals. No significant difference was found in PDW between the IBD and control groups (WMD -0.207%, 95% CI -0.655%, 0.241%). Subgroup analysis by disease type and disease activity showed no change in the differences for PLT, PCT, and MPV in the ulcerative colitis and Crohn's disease groups, as well as the active and inactive groups. Notably, the active group exhibited significantly lower PDW levels than the control group (WMD -1.138%, 95% CI -1.535%, -0.741%).CONCLUSIONS:
Compared with healthy individuals, IBD patients display significantly higher PLT and PCT and significantly lower MPV. Monitoring the clinical manifestations of platelet abnormalities serves as a valuable means to obtain diagnostic and prognostic information. Conversely, proactive measures should be taken to prevent the consequences of platelet abnormalities in individuals with IBD. SYSTEMATIC REVIEW REGISTRATION PROSPERO CRD42023493848.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Enfermedades Inflamatorias del Intestino
/
Volúmen Plaquetario Medio
Límite:
Humans
Idioma:
En
Revista:
BMC Gastroenterol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
China