Unveiling myocardial microstructure shifts: exploring the impact of diabetes in stable CAD patients through CMR T1 mapping.
Diabetol Metab Syndr
; 16(1): 156, 2024 Jul 09.
Article
en En
| MEDLINE
| ID: mdl-38982515
ABSTRACT
BACKGROUND:
This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping.METHODS:
A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed.RESULTS:
Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain.CONCLUSIONS:
CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals. TRIAL REGISTRATION http//www.controlled-trials.com/ISRCTN09454308.
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
Diabetol Metab Syndr
Año:
2024
Tipo del documento:
Article
País de afiliación:
Brasil