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A methodological pipeline for the preclinical evaluation of novel topical agents for the treatment of CRS.
Hale, Samuel J M; Lux, Christian A; Willoughby, James E; Koefoed, Arne; Broderick, David; Biswas, Kristi; Kim, Raymond; Mackenzie, Brett Wagner; Douglas, Richard G.
Afiliación
  • Hale SJM; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Lux CA; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Willoughby JE; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Koefoed A; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Broderick D; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Biswas K; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Kim R; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Mackenzie BW; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
  • Douglas RG; Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Int Forum Allergy Rhinol ; 2024 Jul 16.
Article en En | MEDLINE | ID: mdl-39010849
ABSTRACT
KEY POINTS Novel topical therapeutics require extensive pre-clinical testing to assess efficacy and safety. Antibiofilm or immunosuppressant agents can utilize ex vivo models to measure ciliotoxicity. Agents that are found to be effective and non-toxic ex vivo warrant further investigation in vivo.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Int Forum Allergy Rhinol Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: Int Forum Allergy Rhinol Año: 2024 Tipo del documento: Article País de afiliación: Nueva Zelanda