Structural differences in the cell binding region of human fibronectin molecules isolated from cultured normal and tumor-derived human cells.
FEBS Lett
; 192(1): 71-4, 1985 Nov 11.
Article
en En
| MEDLINE
| ID: mdl-3902506
ABSTRACT
Fibronectins isolated from human plasma (pFN) and from the conditioned media of normal (N-cFN) and tumor (T-cFN) human cells were compared by cathepsin D digestion followed by immunostaining of released fragments with the monoclonal antibody 3E3, specific for the cell binding site. Two different staining patterns were obtained, one specific for pFN and N-cFN, the second common to fibronectins from the 3 different kinds of tumors studied. This indicates structural differences between N-cFN and T-cFN in the cell binding region of the fibronectin molecule.
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Banco de datos:
MEDLINE
Asunto principal:
Fibronectinas
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
1985
Tipo del documento:
Article