Identification of natural inhibitors targeting Trehalase of Anopheles funestus in the management of malaria: A Biocomputational assessment.
J Vector Borne Dis
; 2024 Jul 12.
Article
en En
| MEDLINE
| ID: mdl-39066687
ABSTRACT
BACKGROUND OBJECTIVES:
Anopheles funestus is playing an increasingly important role in malaria transmission in sub-Saharan Africa. Trehalase, an enzyme required for trehalose breakdown, is important for mosquito flight and stress adaptation. Hence, its inhibition has emerged as a promising malaria management strategy.METHODS:
A collection of 1900 natural compounds from the ZINC database were screened against the 3D modeled structure of the A. funestus trehalase protein using in-silico tools. ADMET-AI, a web-based platform, was used to predict the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the selected compounds.RESULTS:
Here in this study, we report 5 natural compounds namely, ZINC00488388, ZINC00488525, ZINC00488566, ZINC00488304, and ZINC00488456 demonstrated strong binding affinity to the trehalase protein. These compounds interacted with critical residues of the trehalase protein and exhibited good drug-like characteristics. INTERPRETATIONCONCLUSION:
These compounds show promise as trehalase protein inhibitors for malaria management. Nonetheless, additional experimental studies are required to optimize these compounds as potential trehalase inhibitors.
Texto completo:
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Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Vector Borne Dis
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2024
Tipo del documento:
Article
País de afiliación:
Arabia Saudita