Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.
J Exp Med
; 162(5): 1726-31, 1985 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-3932582
ABSTRACT
By three criteria, we have demonstrated that B cell stimulatory factor (BSF-1) and B cell differentiation factor (BCDF-gamma) are the same lymphokine. Highly purified preparations of high performance liquid chromatography-purified or affinity-purified BSF-1 had BCDF-gamma activity but not BCDF-mu activity. A monoclonal anti-BSF-1 antibody coupled to Sepharose depleted both BSF-1 and BCDF-gamma activity but not BCDF-mu activity from two different T cell supernatants. Soluble monoclonal anti-BSF-1 blocked the BSF-1 and BCDF-gamma but not the BCDF-mu responses. These results suggest that BSF-1 acts on both resting and activated B cells to induce different effects.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos B
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Antígenos Ly
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Sustancias de Crecimiento
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Antígenos de Superficie
Límite:
Animals
Idioma:
En
Revista:
J Exp Med
Año:
1985
Tipo del documento:
Article