Microsomal mediated metabolism of dialkylaryltriazenes. I. Demethylation of ring halogenated 3,3-dimethyl-1-phenyltriazenes.
J Cancer Res Clin Oncol
; 93(3): 215-20, 1979 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-468884
ABSTRACT
The oxidative N-demethylation was investigated for a series of 3,3-dimethyl-l-phenyl-triazenes. Triazenes, deactivated with halogene atoms in the phenylring, were expected to be better demethylated. The results do indicate a good trend that substitution of the ring with deactivating atoms and extent of demethylation compare well. The percentages of demethylation were For 3,3-dimethyl-l-phenyltriazene, 45%; for 3,3-dimethyl-l (4-chlor-phenyl)-triazene, 92%; for 3,3-dimethyl-l(4-bromophenyl)triazene, 89%; for 3,3-dimethyl-l-(2,4,6-trichlorophenyl)triazene, 122%; and for 3,3-dimethyl-l-l-(2,4,6-tribromophenyl)triazene, 85%.
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Banco de datos:
MEDLINE
Asunto principal:
Triazenos
/
Microsomas Hepáticos
Límite:
Animals
Idioma:
En
Revista:
J Cancer Res Clin Oncol
Año:
1979
Tipo del documento:
Article