The stimulation of murine hepatic aryl hydrocarbon hydroxylase activity in vitro by caffeine.
Cancer Lett
; 8(1): 43-9, 1979 Nov.
Article
en En
| MEDLINE
| ID: mdl-509418
ABSTRACT
The activity of aryl hydrocarbon hydroxylase (AHH) of murine liver is increased by caffeine. However, other analogs of caffeine, such as theophylline, theobromine xanthine, hypoxanthine and uric acid, do not significantly alter AHH activity. The maximal stimulation is observed at a caffeine concentration of approx. 3 mM. The Km of AHH for benzo[a]pyrene is decreased in the presence of caffeine. Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Cafeína
/
Microsomas Hepáticos
/
Hidrocarburo de Aril Hidroxilasas
Límite:
Animals
Idioma:
En
Revista:
Cancer Lett
Año:
1979
Tipo del documento:
Article