Regulation of glutamate receptors: possible role of phosphatidylserine.
Brain Res
; 242(2): 374-7, 1982 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-6288170
ABSTRACT
The polar head group of the phospholipid phosphatidylserine is similar in structure to the glutamate analogue 2-amino-4-phosphonobutyric acid (APB), an antagonist of excitatory transmission in the brain. When tested in ligand binding assays phosphatidylserine and its polar head group components O-phosphoserine and L-alpha-glycerophosphoserine were good displacers of APB-sensitive L-glutamate binding. The polar head group components were also antagonists of synaptic field potentials in the rat dentate gyrus evoked by stimulation of a presumed glutamate-using pathway. These results suggest that phosphatidylserine may regulate the activity of synaptic L-glutamate receptors.
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Banco de datos:
MEDLINE
Asunto principal:
Fosfatidilserinas
/
Encéfalo
/
Receptores de Superficie Celular
/
Glutamatos
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1982
Tipo del documento:
Article