Cholesterol feeding increases low density lipoprotein synthesis.
J Clin Invest
; 72(1): 45-51, 1983 Jul.
Article
en En
| MEDLINE
| ID: mdl-6308052
ABSTRACT
This study examines the effects of increased dietary cholesterol (6 eggs/d) on the metabolism of low density lipoproteins in a group of seven healthy volunteers. Egg supplementation raised high density and low density lipoprotein cholesterol levels by 18 and 40%, respectively. The composition of the low density lipoprotein was unaltered and therefore the number of circulating particles must have increased. Kinetic studies indicated that this was due primarily to a 23% rise in the rate of synthesis of the lipoprotein. Catabolism was also affected. The fractional removal rate of native low density lipoprotein fell by 10% (P less than 0.05). However, the clearance of the 1,2 cyclohexanedione-treated lipoprotein remained unchanged (control fractional clearance rate [FCR] = 0.188 pools/d; cholesterol feeding FCR = 0.183 pools/d). Therefore, the reduction in low density lipoprotein catabolism appeared to be due to a fall in receptor activity. Consequently, an increased sterol load (34.2 mumol/kg per d vs. 27.7 mumol/kg per d in the control phase, P less than 0.02) was channelled into the receptor-independent route during egg feeding.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Colesterol en la Dieta
/
Lipoproteínas LDL
Límite:
Adult
/
Female
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Humans
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Male
Idioma:
En
Revista:
J Clin Invest
Año:
1983
Tipo del documento:
Article