Intestinal uptake and metabolism of auranofin, a new oral gold-based antiarthritis drug.
Science
; 225(4660): 430-2, 1984 Jul 27.
Article
en En
| MEDLINE
| ID: mdl-6429854
ABSTRACT
Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-(triethy lphosphine)- gold(I), an experimental antiarthritis pharmaceutical, metabolized in contact with hamster or rat gut wall to yield the deacetylated form of the drug. This product, 1-thio-beta-D-glucopyranosato-S-(triethylphosphine)gold(I), passed through hamster or rat intestinal wall in an everted gut experiment. The metabolite was separated by high-performance liquid chromatography and characterized by retention time, chemical reactivity to yield a known product, and comparison to a synthetic sample of the metabolite.
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Banco de datos:
MEDLINE
Asunto principal:
Aurotioglucosa
/
Oro
/
Absorción Intestinal
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1984
Tipo del documento:
Article