Enhancement of artificial lung metastases by misonidazole.
Int J Radiat Oncol Biol Phys
; 10(8): 1395-8, 1984 Aug.
Article
en En
| MEDLINE
| ID: mdl-6469763
ABSTRACT
The effect of treatment with the hypoxic cell radiosensitizer misonidazole on the formation of artificial lung metastases was examined. Both single treatments with large doses of misonidazole and fractionated treatments with smaller doses of misonidazole were found to increase the number of lung tumors developing after intravenous injection of EMT6 mouse mammary carcinoma cells. The immunologic and physiologic effects of the nitroimidazole were postulated to be responsible for the enhancement of lung tumor formation.
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Banco de datos:
MEDLINE
Asunto principal:
Fármacos Sensibilizantes a Radiaciones
/
Neoplasias Pulmonares
/
Neoplasias Mamarias Experimentales
/
Misonidazol
/
Nitroimidazoles
Límite:
Animals
Idioma:
En
Revista:
Int J Radiat Oncol Biol Phys
Año:
1984
Tipo del documento:
Article