Effect of 4-cholesten-3-one on steroidogenesis and morphology of rat adrenal cortex.
Endocrinol Exp
; 15(3): 191-8, 1981 Sep.
Article
en En
| MEDLINE
| ID: mdl-6975205
ABSTRACT
The production of corticosteroids from endogenous precursors was decreased in adrenal glands of male rats fed a diet containing one per cent of 4-cholesten-3-one for 3 and 7 days. In contrast, the conversion of labelled progesterone into corticosteroids was only slightly affected as shown by the increased aldosterone to 18-hydroxydeoxycorticosterone ratio. Morphological method revealed lipoid adrenal hyperplasia developing progressively during the observation period. In the adrenal gland, the content of 4-cholesten-3-one rose slightly and, as shown in the experiment with labelled 4-cholesten-3-one, it can serve only as a weakly effective precursor of corticosteroid biosynthesis. Cholesterol content in the adrenals decreased and lipoid hyperplasia could not be explained therefore by cholesterol accumulation.
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Banco de datos:
MEDLINE
Asunto principal:
Colestenos
/
Colestenonas
/
Corteza Suprarrenal
/
Corticoesteroides
Límite:
Animals
Idioma:
En
Revista:
Endocrinol Exp
Año:
1981
Tipo del documento:
Article