Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family.
Oncogene
; 11(10): 2179-84, 1995 Nov 16.
Article
en En
| MEDLINE
| ID: mdl-7478540
ABSTRACT
Complementary DNA (cDNA) encoding a novel member of the receptor tyrosine kinase (RTK) family has been isolated from colon carcinoma tissue. Colon carcinoma kinase 4 (CCK-4) mRNA is highly expressed in human lung tissue and at lower levels in the thyroid gland and ovary. While no mRNA was found in human adult colon tissues, expression varied remarkably in colon carcinoma-derived cell lines. CCK-4 cDNA encodes a chicken KLG-related, 1071 amino acid-long transmembrane glycoprotein containing several genetic alterations within the RTK consensus sequences. These define CCK-4 as a catalytically inactive member of the RTK family of proteins and, in analogy to HER3, suggest a potentially tumor-characteristic role as a signal amplifier or modulator for an as yet unidentified kinase-competent partner.
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Banco de datos:
MEDLINE
Asunto principal:
Moléculas de Adhesión Celular
/
Proteínas Tirosina Quinasas Receptoras
/
Neoplasias del Colon
/
Proteínas de Neoplasias
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Oncogene
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos