Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
Science
; 267(5199): 886-91, 1995 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-7531365
ABSTRACT
B-cell precursor (BCP) leukemia is the most common form of childhood cancer and the second most common form of acute leukemia in adults. Human BCP leukemia was treated in a severe combined immunodeficient mouse model by targeting of the tyrosine kinase inhibitor Genistein (Gen) to the B cell-specific receptor CD19 with the monoclonal antibody B43. The B43-Gen immunoconjugate bound with high affinity to BCP leukemia cells, selectively inhibited CD19-associated tyrosine kinases, and triggered rapid apoptotic cell death. At less than one-tenth the maximum tolerated dose more than 99.999 percent of human BCP leukemia cells were killed, which led to 100 percent long-term event-free survival from an otherwise invariably fatal leukemia. The B43-Gen immuno-conjugate might be useful in eliminating leukemia cells in patients who have failed conventional therapy.
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Banco de datos:
MEDLINE
Asunto principal:
Proteínas Tirosina Quinasas
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Antígenos de Diferenciación de Linfocitos B
/
Antígenos CD
/
Inmunoconjugados
/
Isoflavonas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1995
Tipo del documento:
Article