Characteristic antitumor activity of cytarabine ocfosfate against human colorectal adenocarcinoma xenografts in nude mice.
Cancer Chemother Pharmacol
; 36(6): 459-62, 1995.
Article
en En
| MEDLINE
| ID: mdl-7554036
ABSTRACT
The antitumor activity of cytarabine ocfosfate (SPAC) was tested against human colorectal, gastric and lung adenocarcinoma xenografts in nude mice in comparison with the activities of various antitumor drugs used clinically. SPAC showed higher therapeutic efficacy against human colorectal adenocarcinoma xenografts than against human gastric and lung adenocarcinoma xenografts. SPAC was effective against three of four human colorectal adenocarcinoma xenografts, with efficacy higher than that of 1-beta-D-arabinofuranosylcytosine, fluorouracil, cisplatin, doxorubicin, pirarubicin and vindesine sulfate, but lower than that of mitomycin C and cyclophosphamide. These results indicate that SPAC may be useful for induction and/or postoperative chemotherapy against colorectal adenocarcinomas.
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Banco de datos:
MEDLINE
Asunto principal:
Arabinonucleotidos
/
Neoplasias Colorrectales
/
Adenocarcinoma
/
Citidina Monofosfato
/
Antineoplásicos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Chemother Pharmacol
Año:
1995
Tipo del documento:
Article
País de afiliación:
Japón