Oncogenes, protooncogenes, and tumor suppressor genes in acute myelogenous leukemia.
J Pediatr Hematol Oncol
; 17(2): 101-12, 1995 May.
Article
en En
| MEDLINE
| ID: mdl-7749759
ABSTRACT
In recent years, our understanding of normal human hematopoiesis has expanded greatly. We have increased our knowledge of regulatory growth factors, the receptors through which they act, and the secondary messengers involved in transducing the growth/differentiation signals from the cytoplasmic membrane to the nucleus. This knowledge has revealed potential mechanisms for inducing the neoplastic transformation of hematopoietic cells. This applies in particular to the role of viral oncogenes and cellular protooncogenes and, more recently, to the role of tumor suppressor genes. Protooncogenes are intimately involved in the processes of cell proliferation and differentiation. Therefore, any amplification, mutation, structural alteration, or change in transcriptional regulation of protooncogenes might lead to or be associated with induction of the malignant phenotype. Based on the importance of these genes in leukemogenesis and the maintenance of the malignant phenotype, it seems reasonable to hypothesize that targeted disruption of leukemogenic genes may be of therapeutic value.
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Banco de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Proto-Oncogenes
/
Leucemia Mieloide Aguda
/
Genes Supresores de Tumor
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Pediatr Hematol Oncol
Asunto de la revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Año:
1995
Tipo del documento:
Article
País de afiliación:
Estados Unidos