The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Biol Psychiatry
; 37(6): 369-75, 1995 Mar 15.
Article
en En
| MEDLINE
| ID: mdl-7772645
ABSTRACT
Twenty patients, diagnosed as suffering from treatment-resistant major depression, were treated with one or more drugs that decrease corticosteroid biosynthesis. Nine were psychotic, 11 nonpsychotic. Seventeen completed the treatment (8 psychotic, 9 nonpsychotic); 13 responded (5 psychotic, 8 nonpsychotic; 11 responded completely (i.e., a drop in the Hamilton Depression Scale of at least 50%, to < or = 15), and 2 responded partially. The mean age of the responders (45.2 +/- 12.6 years) did not differ significantly from that of the nonresponders (48.7 +/- 12/3). Data were analyzed in the following categories; (1) the presence or absence of psychosis, (2) response or nonresponse to treatment, and (3) the drug(s) used (aminoglutethimide, ketoconazole, or a combination of either of these with metyrapone). The patients improved over time on the Hamilton Depression Scale independent of the medication used. Responders demonstrated improvement in mood, insomnia, anxiety, diurnal variation, paranoia and obsessive compulsiveness. Nonpsychotics responded better than psychotics.
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Banco de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
/
Trastorno Bipolar
/
Corticoesteroides
/
Trastorno Depresivo
/
Aminoglutetimida
/
Cetoconazol
/
Metirapona
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biol Psychiatry
Año:
1995
Tipo del documento:
Article
País de afiliación:
Canadá