The use of intravenous pentamidine as prophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection.

ABSTRACT

The purpose of this study is to report on the use of monthly intravenous pentamidine as prophylaxis against Pneumocystis carinii pneumonia (PCP) within a central London HIV unit. A retrospective case note analysis of HIV-seropositive individuals using intravenous pentamidine as PCP prophylaxis was carried out. Aspects examined included reasons for using the regimen, compliance, adverse reactions and episodes of PCP. Eight patients were studied. There was no prophylaxis failure in 5 patients. Three patients developed PCP whilst on the regimen, although their compliance was poor. In patients who are intolerant of established prophylaxis regimens, intravenous pentamidine may be a useful alternative. It is well tolerated, although compliance is the main problem. Further prospective studies are indicated to assess its efficacy.