Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease.
J Neuroimmunol
; 55(2): 143-52, 1994 Dec.
Article
en En
| MEDLINE
| ID: mdl-7829664
ABSTRACT
Intracerebral (i.c.) inoculation of susceptible strains of mice with Theiler's murine encephalomyelitis virus (TMEV) results in immune-mediated demyelination. We examined the role of interferon (IFN)-gamma in this virally induced pathogenesis. Intraperitoneal (i.p.) injection of susceptible mice with an IFN-gamma-neutralizing monoclonal antibody (mAb), DB-1, resulted in a significantly accelerated onset of disease. The anti-IFN-gamma mAb-treated animals showed a strong delayed-type hypersensitivity (DTH) response to the virus similar to that of control mAb-treated animals. Treatment with anti-IFN-gamma mAb had no significant effect on the clinical course of disease. However, intracerebral administration of recombinant IFN-gamma significantly accelerated the onset of TMEV-induced disease, as well as enhanced TMEV-specific T cell proliferation and DTH responses. The enhancing effect of IFN-gamma was completely abrogated by simultaneous treatment with anti-IFN-gamma mAb. Collectively, our data suggest that the level of IFN-gamma plays a key role in the TMEV-induced inflammatory response and a perturbation of this balance may result in an alteration in the course of the demyelinating disease.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Interferón gamma
/
Enfermedades Desmielinizantes
/
Theilovirus
Límite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Año:
1994
Tipo del documento:
Article