Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120.
AIDS Res Hum Retroviruses
; 9(10): 957-62, 1993 Oct.
Article
en En
| MEDLINE
| ID: mdl-7904170
ABSTRACT
Similarly to HIV-infected cells, recombinant HIV-1 glycoprotein 120 induces acid-labile interferon production in peripheral blood mononuclear cells from healthy donors. Acid lability of this interferon is due to the presence of both IFN-alpha and -gamma molecules. In fact, although not revealed by neutralization of antiviral activity with antibody to IFN-gamma, the presence of IFN-gamma was shown both immunoenzymatically and by detection of specific mRNA in gp120-stimulated cells. The source of IFN-gamma appears to be a T cell present in the CD4-enriched subpopulation. Cultures treated with monoclonal antibodies to the ICAM-1 and LFA-1 adhesion molecules showed an impaired release of both IFN types after gp120 stimulation, suggesting a crucial role of cell-to-cell interactions in the process leading to IFN production. Our data suggest that the HIV envelope glycoprotein could be responsible for the induction of endogenous IFN-alpha and -gamma observed in AIDS patients.
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Banco de datos:
MEDLINE
Asunto principal:
Proteína gp120 de Envoltorio del VIH
/
Regulación de la Expresión Génica
/
Subgrupos de Linfocitos T
/
Interferón gamma
/
Interferón-alfa
Límite:
Humans
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Asunto de la revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia