Serum antibody for somatostatin-14 and prodynorphin 209-240 in patients with obsessive-compulsive disorder, schizophrenia, Alzheimer's disease, multiple sclerosis, and advanced HIV infection.
Biol Psychiatry
; 35(5): 335-44, 1994 Mar 01.
Article
en En
| MEDLINE
| ID: mdl-7912113
ABSTRACT
Patients with obsessive-compulsive disorder (OCD) demonstrated significant levels of antibody for somatostatin-28, its C-terminal fragment somatostatin-14, and prodynorphin. In contrast there were lower levels of reactivity for somatostatin-28(1-14) (the N-terminal fragment of somatostatin-28) and negligible reactivity for several other peptides including beta-endorphin and corticotropin. Healthy volunteers and disease controls [schizophrenia, Alzheimer's disease, multiple sclerosis, and subjects with advanced human immunodeficiency virus (HIV) infection] exhibited negligible reactivity. These data raise the consideration of an autoimmune mechanism for some OCD.
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Banco de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Esquizofrenia
/
Encefalinas
/
Somatostatina
/
Seropositividad para VIH
/
Enfermedad de Alzheimer
/
Anticuerpos
/
Esclerosis Múltiple
/
Trastorno Obsesivo Compulsivo
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biol Psychiatry
Año:
1994
Tipo del documento:
Article