Induction of delayed afterdepolarizations and triggered arrhythmias in isolated Purkinje fibers: comparison of resibufogenin and acetylstrophanthidin.
Zhongguo Yao Li Xue Bao
; 15(2): 97-102, 1994 Mar.
Article
en En
| MEDLINE
| ID: mdl-8010120
ABSTRACT
The purpose of this study was to compare the electrotoxicological effects of resibufogenin (RBG) (n = 14) with acetylstrophanthidin (AS) (n = 14) to induce delayed afterdepolarization (DAD) and triggered activity (TA), and their alteration of the electrophysiological properties in sheep cardiac Purkinje fibers using the extracellular electrograms, signal averaging, and standard microelectrode techniques simultaneously. The results indicated 1) Lower toxic dose of RBG (0.52 mumol.L-1) and AS (0.25 mumol.L-1) induced intracellular and extracellular DAD (DAD-I and DAD-E) at pacing cycle length of 990 and 690 ms. 2) Higher toxic dose of RBG (2.6 mumol.L-1) and AS (5.0 mumol.L-1) induced DAD and TA, nonsustained or sustained premature action potential and oscillatory potentials; 3) At the beginning period of superfusing the drugs, both RBG and AS caused changes of the electrophysiological characteristics. This study demonstrates that the electro-toxicological characteristics and electrophysiological properties of RBG are similar to that of AS and suggests that RBG belongs to the family of digitalis-like drugs.
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Banco de datos:
MEDLINE
Asunto principal:
Arritmias Cardíacas
/
Ramos Subendocárdicos
/
Estrofantidina
/
Bufanólidos
/
Cardiotónicos
Límite:
Animals
Idioma:
En
Revista:
Zhongguo Yao Li Xue Bao
Año:
1994
Tipo del documento:
Article