Uric acid homeostasis in lean and obese girls during pubertal development.
Metabolism
; 43(7): 819-21, 1994 Jul.
Article
en En
| MEDLINE
| ID: mdl-8028503
ABSTRACT
Serum uric acid concentration and fractional excretion were evaluated in lean (n = 67) and obese (n = 56) girls before and during pubertal development. In both lean and obese girls, uricemia gradually increased as puberty advanced. Obese girls were hyperuricemic compared with lean controls (prepubertal 184 +/- 83 v 130 +/- 29 mumol/L, P = .007; Tanner stage II-III 190 +/- 53 v 178 +/- 47 mumol/L, NS; Tanner stage IV-V 232 +/- 53 v 191 +/- 53 mumol/L, P = .02). Fractional excretion of urate decreased with puberty in lean girls (6.46% +/- 2.29%, 4.61% +/- 2.48%, and 3.54% +/- 1.84%), but not in obese subjects (3.74% +/- 2.27%, 4.01% +/- 1.90%, and 4.26% +/- 2.26%). Urate homeostasis was similar in prepubertal obese girls and in adolescent lean controls. We conclude that an increased serum urate concentration occurring at puberty may be due to decreased renal clearance of urate in lean girls, and at least in part to urate overproduction in obese subjects. Obesity may prematurely evoke changes in urate metabolism usually observed at puberty.
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Banco de datos:
MEDLINE
Asunto principal:
Ácido Úrico
/
Pubertad
/
Obesidad
Límite:
Adolescent
/
Child
/
Female
/
Humans
Idioma:
En
Revista:
Metabolism
Año:
1994
Tipo del documento:
Article
País de afiliación:
Italia