Neuropeptide Y potentiates via Y2-receptors the inhibitory effect of noradrenaline in rat locus coeruleus neurones.
Naunyn Schmiedebergs Arch Pharmacol
; 348(5): 546-8, 1993 Nov.
Article
en En
| MEDLINE
| ID: mdl-8114954
ABSTRACT
Intracellular recordings were carried out in a pontine slice preparation of the rat brain containing the locus coeruleus (LC). Pressure application of noradrenaline with various pulse durations inhibited the spontaneous frequency of action potentials and hyperpolarized the membrane. Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive. These results are compatible with the presence of Y2-type NPY-receptors at the cell somata of LC neurones.
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Banco de datos:
MEDLINE
Asunto principal:
Neuropéptido Y
/
Locus Coeruleus
/
Norepinefrina
/
Receptores de Neuropéptido
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
Año:
1993
Tipo del documento:
Article
País de afiliación:
Alemania