Efficacy and tolerability of brodimoprim in bacterial otitis media in children. Controlled study versus cefaclor.
J Chemother
; 5(6): 551-5, 1993 Dec.
Article
en En
| MEDLINE
| ID: mdl-8195856
ABSTRACT
78 pediatric patients affected by acute otitis media were selected and randomized into two balanced groups of treatment brodimoprim, at the dosage of 200 mg once-a-day on the first day and of 100 mg once-a-day on the following days, and cefaclor at a dosage of 40 mg/Kg/day in three doses. Brodimoprim resulted more efficacious in the reduction of symptoms, especially hypoacusis and tinnitus (p < 0.05 between treatments); tympanometry showed a higher number of normalizations in the brodimoprim group, without significant differences between treatments. Both drugs resulted active against most of isolated bacterial strains. Side effects were reported in 4 patients treated with brodimoprim and in 6 patients in the control group.
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Banco de datos:
MEDLINE
Asunto principal:
Otitis Media
/
Infecciones Bacterianas
/
Trimetoprim
/
Cefaclor
Tipo de estudio:
Clinical_trials
Límite:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Chemother
Asunto de la revista:
ANTINEOPLASICOS
/
TERAPIA POR MEDICAMENTOS
Año:
1993
Tipo del documento:
Article
País de afiliación:
Italia