Age-related digoxin-alprazolam interaction.
Clin Pharmacol Ther
; 54(1): 42-4, 1993 Jul.
Article
en En
| MEDLINE
| ID: mdl-8330464
ABSTRACT
A case report of dramatic increases in serum digoxin levels after alprazolam administration prompted our investigation. Twelve inpatients receiving long-term digoxin (0.25 mg daily) randomly received oral administration of either 1.0 or 0.5 mg alprazolam per day for 7 days. In each dosage group, three patients were older than and three were younger than 65 years of age. The area under the concentration-time curve for serum digoxin increased significantly in patients receiving 1 mg alprazolam daily, and this increase was more pronounced in patients older than 65 years of age. Clinical digoxin toxicity developed in one elderly patient who was receiving 1 mg/day alprazolam.
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Banco de datos:
MEDLINE
Asunto principal:
Alprazolam
/
Envejecimiento
/
Digoxina
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
1993
Tipo del documento:
Article
País de afiliación:
Turquía