Localization of a fibrin polymerization site complementary to Gly-His-Arg sequence.
FEBS Lett
; 320(3): 239-42, 1993 Apr 12.
Article
en En
| MEDLINE
| ID: mdl-8462692
ABSTRACT
Dansyl-labeled tetrapeptide Gly-His-Arg-Pro which mimics the central fibrin polymerization site was used to investigate its binding to a number of fibrinogen fragments containing different numbers of domains. The tetrapeptide was found to bind to fragments DH(95 kDa), DL(82 kDa) and DY(63 kDa) but not to the TSD(28 kDa) fragment. The DY fragment differs from the TSD by the presence of beta and beta C domains. Therefore these domains, which are formed by the C-terminal part of the beta chain, possess a polymerization site complementary to the Gly-His-Arg containing counterpart.
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Banco de datos:
MEDLINE
Asunto principal:
Fibrinógeno
/
Fibrina
Límite:
Animals
Idioma:
En
Revista:
FEBS Lett
Año:
1993
Tipo del documento:
Article