Differential expression of pyrimidine dimer-binding proteins in normal and UV light-treated vertebrate cells.
Photochem Photobiol
; 57(4): 655-62, 1993 Apr.
Article
en En
| MEDLINE
| ID: mdl-8506394
ABSTRACT
The expression of UV damage-specific DNA-binding proteins was examined in various phylogenetically distant species with differing DNA repair phenotypes. Two distinct constitutive DNA-binding activities, one specific for cyclobutane pyrimidine dimers and the other for non-cyclobutane dimer photoproducts, were detected. The expression of these binding activities was found to be variable throughout the animal kingdom cold-blooded vertebrates show a constitutive cyclobutane dimer-binding activity exclusively, and primates reveal only non-cyclobutane binding activity. In contrast, birds and marsupials appear to express both types of binding activities. The kinetics of expression (rather than the constitutive presence) of these UV damage-specific DNA-binding activities after UV treatment correlate with the cell's capacity for DNA repair. In addition, cyclobutane pyrimidine dimer-binding activities could be detected only in cells with established photoreactivating activity.
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Banco de datos:
MEDLINE
Asunto principal:
Dímeros de Pirimidina
/
Rayos Ultravioleta
/
Daño del ADN
/
Proteínas de Unión al ADN
/
Reparación del ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Photochem Photobiol
Año:
1993
Tipo del documento:
Article