[Congenital adrenal hyperplasia and testicular hypertrophy]. / Hyperplasie congénitale des surrénales et hypertrophie testiculaire.
Arch Pediatr
; 2(12): 1167-72, 1995 Dec.
Article
en Fr
| MEDLINE
| ID: mdl-8547996
ABSTRACT
BACKGROUND:
Testicular tumors have been reported in boys and adolescents with congenital adrenal hyperplasia (CAH) inadequately controlled by hormonal therapy. CASE REPORTS Two adolescents were treated for CAH due to 21-hydroxylase deficiency. They developed hyperplastic nodular testes at the age of 16 and 17 years, respectively. CAH in both was inadequately controlled as confirmed by hormonal studies. The tumors regressed after adequate steroid therapy in the first patient but persisted in the second patient despite normalization of 17-OH progesterone and plasma renin activity.CONCLUSION:
Testicular ultrasonography should be systematic in all male patients with CAH since radiological findings are earlier than clinical manifestations. The ACTH-dependent tumors require intensification of hormonal therapy in order to obtain tumoral regression and to prevent infertility.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Testiculares
/
Hiperplasia Suprarrenal Congénita
Tipo de estudio:
Diagnostic_studies
Límite:
Adolescent
/
Humans
/
Male
Idioma:
Fr
Revista:
Arch Pediatr
Año:
1995
Tipo del documento:
Article
País de afiliación:
Francia