A Myxococcus xanthus cell density-sensing system required for multicellular development.
FEMS Microbiol Lett
; 139(2-3): 89-95, 1996 Jun 01.
Article
en En
| MEDLINE
| ID: mdl-8674994
ABSTRACT
Progression through early Myxococcus xanthus multicellular fruiting body development requires the generation of and response to extracellular A signal. Extracellular A signal is a specific set of amino acids at an extracellular concentration greater than 10 muM. It functions as a cell density signal during starvation that allows the cells to sense that a minimal cell density has been reached and development can proceed. The generation of extracellular A signal requires the products of three asg genes. They have recently been identified as AsgA, a fused two-component histidine protein kinase and response regulator; AsgB, a putative DNA-binding protein; and AsgC, the M, xanthus major sigma factor. Other elements of the A signaling pathway map to the sasB locus and appear to be A signal transducers. These elements are regulators of the earliest A signal-dependent gene, whose promoter is a member of the sigma-54 family. Continued study of the A signaling pathway is expected to identify additional components of this network required for the complex behavioural response of fruiting body formation.
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Banco de datos:
MEDLINE
Asunto principal:
Myxococcus xanthus
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
FEMS Microbiol Lett
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos