Stimulation of 5-HT2A receptors in the paraventricular hypothalamus attenuates neuropeptide Y-induced hyperphagia through activation of corticotropin releasing factor.
Brain Res
; 708(1-2): 173-6, 1996 Feb 05.
Article
en En
| MEDLINE
| ID: mdl-8720874
ABSTRACT
The effect of 5-HT1 and 5-HT2 receptor agonists administered into the paraventricular hypothalamus was studied on the hyperphagia caused by neuropeptide Y (NPY) injected into the same area. The 5-HT2A/2C receptor agonist DOI (10-20 nmol/0.5 microliter) significantly reduced NPY overeating while the 5-HT1A/1B receptor agonist RU 24969 (3.5-14 nmol/0.5 microliter) and the 5-HT1B/2C receptor agonist mCPP (5-20 nmol/0.5 microliter) had no such effect. The 5-HT2A receptor antagonist spiperone (5 microgram/0.5 microliter) and the corticotropin releasing factor antagonist alpha-helical-CRF9-41 (0.5-1 micrograms/0.5 microliter) completely antagonized the effect of 10 nmol DOI.
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Banco de datos:
MEDLINE
Asunto principal:
Neuropéptido Y
/
Hormona Liberadora de Corticotropina
/
Hiperfagia
/
Receptores de Serotonina
/
Agonistas de Receptores de Serotonina
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1996
Tipo del documento:
Article
País de afiliación:
Italia