Sodium polystyrene sulfonate treatment for lithium toxicity: effects on serum potassium concentrations.
Acad Emerg Med
; 3(4): 333-7, 1996 Apr.
Article
en En
| MEDLINE
| ID: mdl-8881542
ABSTRACT
OBJECTIVE:
To examine the effects of sodium polystyrene sulfonate (SPS) on serum potassium (K) concentrations in mice pretreated with parenteral lithium (Li).METHODS:
A placebo-controlled murine model trial of SPS therapy following IV Li was performed. Sixty male CD-1 mice weighing 18-22 g were administered either IV LiCl (125 mg/kg) or a control solution (normal saline). Half of the mice in each of these groups were then given orogastric water 20, 40, 90, 150, and 210 minutes after LiCl or normal saline; the other half received SPS (5 g/kg/dose) at equivalent times. Subgroups of each of these four groups were sacrificed at one, two, and six hours after pretreatment and the serum was analyzed for K concentration. Serum K concentrations for the various groups were compared with analysis of variance and Newman-Keuls tests for the comparison of multiple means.RESULTS:
A statistically significant reduction of serum K concentrations occurred in the animals that received SPS treatment following either IV saline or LiCl solutions. The degree of K reduction that resulted from the combination of LiCl and SPS treatment (35% reduction at six hours, compared with the placebo-treated controls) was larger than that which resulted from either IV Li with oral water (15% reduction) or IV saline with oral SPS (20% reduction).CONCLUSIONS:
These findings suggest that development of hypokalemia may represent a potential limitation in the use of SPS in the treatment for Li toxicity.
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Banco de datos:
MEDLINE
Asunto principal:
Poliestirenos
/
Potasio
/
Litio
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Acad Emerg Med
Asunto de la revista:
MEDICINA DE EMERGENCIA
Año:
1996
Tipo del documento:
Article
País de afiliación:
Estados Unidos