Relationship between albumin excretion rate, ambulatory blood pressure and left ventricular hypertrophy in mild hypertension.
J Hypertens
; 13(12 Pt 2): 1796-800, 1995 Dec.
Article
en En
| MEDLINE
| ID: mdl-8903654
ABSTRACT
OBJECTIVE:
To study the relationship of urinary albumin excretion to ambulatory blood pressure and other cardiovascular risk factors in borderline to mild hypertension. PATIENTS ANDMETHODS:
We studied 779 patients with borderline to mild hypertension (mean +/- SEM age 33 +/- 0.3 years; mean +/- SEM office blood pressure 146 +/- 0.4/94 +/- 0.2 mmHg) at 17 hypertension clinics in northeast Italy. Office and 24-h blood pressures were recorded with simultaneous urine collection for albumin measurement. In 510 subjects, left ventricular mass was measured by echocardiography.RESULTS:
Subjects with overt (> or = 30 mg/24 h) and borderline (16-29 mg/24 h) microalbuminuria had similar 24-h blood pressure levels, higher than those in the subjects without microalbuminuria. In the univariate and multiple regression analyses the albumin excretion rate was closely correlated with 24-h systolic blood pressure and not related to age, body mass index, metabolic parameters, lifestyle factor and degree of left ventricular hypertrophy.CONCLUSIONS:
Borderline values of urinary albumin excretion (16-29 mg/24 h) may be clinically relevant in subjects with borderline to mild hypertension. Renal and cardiac damage do not develop in parallel in the initial phases of hypertension.
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Banco de datos:
MEDLINE
Asunto principal:
Hipertrofia Ventricular Izquierda
/
Albuminuria
/
Hipertensión
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Hypertens
Año:
1995
Tipo del documento:
Article
País de afiliación:
Italia