Colchicine versus prednisone as treatment of usual interstitial pneumonia.
Mayo Clin Proc
; 72(3): 201-9, 1997 Mar.
Article
en En
| MEDLINE
| ID: mdl-9070193
ABSTRACT
OBJECTIVE:
To assess the results with colchicine and prednisone as initial single-drug therapy in patients with usual interstitial pneumonia (UIP). MATERIAL ANDMETHODS:
We reviewed the serial pulmonary function test results in 22 patients with typical clinical and high-resolution computed tomographic features of UIP who were treated with colchicine as initial single-agent therapy and compared them with a group of 22 historical patients with UIP of similar severity diagnosed by open-lung biopsy who were given prednisone as initial single-drug therapy.RESULTS:
No significant difference was detected in the rate of decline of pulmonary function or in the time to "failure" between the two study groups. A trend was suggested for more rapid decline of pulmonary function in the prednisone-treated than in the colchicine-treated group. The design of this study does not allow distinction between a possible beneficial effect of colchicine and a possible adverse effect related to weaning from high-dose prednisone. Colchicine was well tolerated; few side effects other than mild diarrhea were noted in those patients able to take the drug long enough to return for pulmonary function testing at 3 months. In comparison, the side effects of prednisone were more serious and were not always reversible with cessation of therapy.CONCLUSION:
This study lends further support to the assumption that colchicine may be a satisfactory and less hazardous substitute for prednisone in the treatment of patients with UIP.
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Banco de datos:
MEDLINE
Asunto principal:
Prednisona
/
Colchicina
/
Enfermedades Pulmonares Intersticiales
/
Antiinflamatorios
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mayo Clin Proc
Año:
1997
Tipo del documento:
Article
País de afiliación:
Estados Unidos