Changes in cardiac adrenomedullin concentration in renovascular hypertensive rats.
Hypertens Res
; 20(2): 113-7, 1997 Jun.
Article
en En
| MEDLINE
| ID: mdl-9220275
ABSTRACT
We assessed changes in tissue and plasma adrenomedullin levels in two-kidney, one-clip renovascular hypertensive rats. Four weeks after clipping, adrenomedullin concentrations were significantly higher in the cardiac ventricles and lower in the left atrium than the respective values in sham-operated rats. The left ventricular adrenomedullin concentration significantly correlated with systolic blood pressure and the degree of cardiac hypertrophy. No difference was noted in the adrenomedullin concentrations of the adrenal gland, aorta, lung, kidneys, or plasma between the two groups. These findings indicate possible involvement of cardiac adrenomedullin in this model of hypertension.
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Banco de datos:
MEDLINE
Asunto principal:
Péptidos
/
Hipertensión Renovascular
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Hypertens Res
Asunto de la revista:
ANGIOLOGIA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón