The sulfatase gene family.
Curr Opin Genet Dev
; 7(3): 386-91, 1997 Jun.
Article
en En
| MEDLINE
| ID: mdl-9229115
ABSTRACT
During the past few years, molecular analyses have provided important insights into the biochemistry and genetics of the sulfatase family of enzymes, identifying the molecular bases of inherited diseases caused by sulfatase deficiencies. New members of the sulfatase gene family have been identified in man and other species using a genomic approach. These include the gene encoding arylsulfatase E, which is involved in X-linked recessive chondrodysplasia punctata, a disorder of cartilage and bone development. Another important breakthrough has been the discovery of the biochemical basis of multiple sulfatase deficiency, an autosomal recessive disorder characterized by a severe of all sulfatase activities. These discoveries, together with the resolution of the crystallographic structure of sulfatases, have improved our understanding of the function and evolution of this fascinating family of enzymes.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Sulfatasas
/
Errores Innatos del Metabolismo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Genet Dev
Asunto de la revista:
GENETICA
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia