Identification and measurement of beta-endorphin levels in the skin during induced hair growth in mice.
Biochim Biophys Acta
; 1336(2): 315-22, 1997 Aug 29.
Article
en En
| MEDLINE
| ID: mdl-9305804
ABSTRACT
We describe new and effective techniques for extracting proopiomelanocortin (POMC)-derived peptides from mammaliar skin. Using this methodology (hot-acid extraction) and two independent HPLC-controlled RIA systems, we identify beta-endorphin peptide in mammalian skin and demonstrate significant hair cycle-dependent fluctuations in both the skin concentration and the in situ expression pattern of beta-endorphin (sebaceous glands) during the entire murine hair cycle. The observed anagen (growth phase) associated increase in beta-endorphin concentration and its decline during the follicle involution (catagen) or resting (telogen) phase raise the possibility of a regulatory function of this neuropeptide in cyclic changes of skin physiology.
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Banco de datos:
MEDLINE
Asunto principal:
Piel
/
Betaendorfina
/
Cabello
Tipo de estudio:
Diagnostic_studies
Límite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1997
Tipo del documento:
Article
País de afiliación:
Alemania