The clinical impact of teniposide in the treatment of elderly patients with small-cell lung cancer.
Am J Clin Oncol
; 20(5): 477-8, 1997 Oct.
Article
en En
| MEDLINE
| ID: mdl-9345331
ABSTRACT
Teniposide (VM26) has been claimed to be active with a moderate toxicity in elderly patients affected by small-cell lung cancer (SCLC). Twenty-two patients with SCLC older than 65 years received VM26 as first-line chemotherapy at a dose of 60 mg/m2 on 5 consecutive days every 3 weeks. Age distribution ranged from 67 to 80 years (median 72 years). Fourteen patients were men and eight were women. Twelve patients had limited disease (LD) and ten extensive disease (ED). One patient (LD) had a complete response, and four (3 LD, 1 ED) achieved a partial response for an overall response rate of 22.7% (95% CI 6-40%). The most frequent toxicity was myelosuppression 20 and 15% of patients had grade 3 leukopenia and thrombocytopenia, respectively. Our results seem to suggest that VM26 by this schedule is moderately effective in elderly patients with SCLC, and it cannot be recommended as a routine treatment.
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Banco de datos:
MEDLINE
Asunto principal:
Tenipósido
/
Carcinoma de Células Pequeñas
/
Neoplasias Pulmonares
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Clin Oncol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Italia