Gene expression of gonadotropin-releasing hormone, but not its receptor, in human endometrium and decidua.
Mol Cell Endocrinol
; 135(2): 165-8, 1997 Dec 12.
Article
en En
| MEDLINE
| ID: mdl-9484912
ABSTRACT
Gonadotropin-releasing hormone (GnRH) has been reported to exist in extrahypothalamic tissues such as the placenta, gonads and mammary glands. While we have reported the presence of GnRH-mRNA in the rodent uterus, there have been no reports concerning gene expression of GnRH and its receptor (GnRH-R) in human endometrial tissue. In order to investigate the role of GnRH as a local regulator in the human endometrium, we examined the gene for GnRH and GnRH-R in non-pregnant endometrium and decidua of early pregnancy. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we found GnRH-mRNA but not GnRH-R-mRNA transcripts in the human endometrium and decidua at 7-9 weeks gestation. This is the first report that suggests GnRH gene expression in the human endometrium/decidua.
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Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Gonadotropina
/
Receptores LHRH
/
Decidua
/
Endometrio
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
1997
Tipo del documento:
Article
País de afiliación:
Japón