Characterization of the Wiskott-Aldrich syndrome protein and its role in the disease.
Curr Opin Immunol
; 10(4): 407-12, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9722916
ABSTRACT
Wiskott-Aldrich syndrome is an X-linked disorder characterized by thrombocytopenia, eczema and immunodeficiency. The Wiskott-Aldrich syndrome protein and the gene that encodes it have been identified by positional cloning and the protein has been shown to contain a pleckstrin-homology domain, a GTPase-binding domain, a proline-rich region and a verprolin/cofilin homology domain. Subsequent studies suggest that the protein is involved in signal transduction and the regulation of the cytoskeleton.
Buscar en Google
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Wiskott-Aldrich
/
Proteínas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Japón